Schematic illustration of activated and inhibited Wnt/?-catenin pathway. “WNT ON condition?? On ligation of Wnts for their receptors composed of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3?. Subsequently, stabilized ?-catenin translocates into the nucleus and binds to TCF/LEF transcri… Read More

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